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The Rise and the Rise of Childhood cancers

The Rise and the Rise of Childhood cancers

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A Quiet but Alarming Rise

We live in exciting times where AI has emerged as a clear winner and therefore the past decade has seen advances we couldn't phantom. What we also cannot ignore is the rise in number of cancers and new cancer drugs coming out of research everyday.

Children (0–18 years of age) however were always considered a healthy population and it's quite astonishing to see that the burden of childhood cancers is accelerating at a fast rate. The global burden of diagnosed cases every year is almost 400,000 and India alone accounts for approximately 70,000 cases a year.

While India is still battling malnutrition, pneumonias and diarrhoeas in children with an alarming mortality and morbidity — this comes as a huge hit.


Have Childhood Cancers Actually Increased?

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Have childhood cancers truly increased — or are they simply being diagnosed more because of better diagnostic tools available?

Although there is insufficient data to support that food, preservatives, mobile radiations and other environmental factors can increase the risk of cancers in children, certain facts are well established:

⚠️ Proven risk factors

Infections like Hepatitis B Virus (HBV) and Human Papilloma Virus (HPV) in childhood can lead to some adult cancers. Obesity and Diabetes in children leads to lifelong risk for adult cancers. Children must be exposed to healthy food and lifestyle choices from the very start.


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The Most Common Childhood Cancers

Unlike adult cancers, childhood cancers have no associated cause or genetic predisposition and hence screening for them is not available. Only 10% of childhood cancers are linked to certain genetic conditions.

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Leukemias
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Brain Tumors
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Lymphomas
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Neuroblastoma
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Wilms Tumors
🧬 Genetic exception

Children with Down Syndrome are at a higher risk of developing Acute Myeloid Leukemia and can be screened every decade of their life for it. The maximum cases are diagnosed at age 2–6 years — the crucial period of brain and physical growth — hence they must be treated with caution.


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The Silver Lining — Cure Rates

Childhood cancers, if diagnosed early and adequately treated, have an 80% cure rate in high income countries. This is a remarkable silver lining that comes with the condition.

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80%
High Income Countries
Early diagnosis + full access to treatment, specialists & transplant units
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30%
Low & Middle Income Countries
Including India — due to gaps in diagnosis, access and financial support

This poor cure rate is due to multiple overlapping barriers that compound one another:

🔍Delayed or inadequate diagnosis
🏨Inaccessible or unavailable treatment
🚪Abandonment of therapy mid-way
⚗️Death from treatment toxicity or side effects
🔄Relapses after initial treatment
💸Financial constraints on families
👨⚕️Lack of pediatric cancer specialists
🏗️No chemotherapy day care centres or BMT units
📍 India's specific gap

In a country like ours there is a lack of pediatric cancer specialists and healthcare setups (chemotherapy daycare centres and bone marrow transplant) leading to a critical gap in diagnosis and management. The journey to 80% is near — if we can bridge these gaps.


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What We Can Do

A clear roadmap exists to bring our cure rates on par with the world. Here's what needs to happen:

1
A Single National Initiative to establish chemotherapy and transplant units all across the country should be aimed for.
2
Essential cancer medicines should be made available freely from government setups.
3
Establishing a centralized financial aid which can complete the entire treatment so that we can stop abandonment and relapses would be a game changer.
4
Private and government joint ventures can bridge this gap at the earliest to bring smiles for our tiny heroes.
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Dr. Neha Singh
M.B.B.S, M.D (Pediatrics), F.I.A.P (Pediatric Hemato-Oncology and BMT)
L.L.B, MBA (Harvard Business School)
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